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1) The activity of the following enzyme is affected by biotin deficiency____________? a. Transketolase b. Dehydrogenase c. Oxidase d. Carboxylase
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2) The deficiency of thiamine can be identified by measuring the red cell______________? a. Transketaolase b. Transaldolase c. Alpha ketoglutarate dehydrogenase d. Pyruvate dehydrogenase
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3) Competitive enzyme inhibition will cause_____________? a. Decrease of km and increase of Vmax b. increase of km and increase of Vmax c. Decrease of km and decrease of Vmax d. Increase of km and Unchanged of Vmax
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4) Which of the following is correct of the pyruvate dehydrogenase enzyme complex ? a. It is present in cytoplasm b. Catalyzes the conversion of pyruvate to oxaloacetate c. Requires TPP as cofactor d. Catalyzes a reversible reaction
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5) Dehydrogenase used as coenzymes all of the following, except________________? a. FMN b. FAD c. NADP+ d. Ferro protoporphyrin
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6) Benzidine test is positive with the enzyme______________? a. Cytochrome oxidase b. Dehydrogenase c. Hydrolase d. Peroxidase
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7) Key glycolytic enzymes_____________? a. Phosphofructokinase b. Hexokinase c. Pyruvate kinase d. Glucose 1,6 diphosphatase
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8) Multiienzyme complex in human_______________? a. Fatty acid synthetase b. Malonyl CoA carboxylase c. Carbomoyl Phosphate synthetase d. Adenosine phospho ribosyl transferase
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9) Which of the following is NOT a characteristic feature of allosteric enzymes ? a. They are multienzyme complex b. Follow Michaelis-Menton Kinetics c. Presence of Modulator site d. Give sigmoid shaped curve
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10) A example of a preventive antioxidant is_______________? a. Catalase b. Tocopherol c. Superoxide dismutase d. Urate
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11) LDH has following number oflsoenzymes________________? a. 5 b. 3 c. 11 d. 2
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12) One of the earliest symptoms of Vit. A deficiency is________________? a. Nyctalopia b. Xerophthalmia c. Bitot’s spot d. Keratomalacia
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13) The enzyme phosphofructo kinase-1 is strongly activated by_______________? a. Cyclic AMP b. Adenosine tri phosphate c. Citrate d. Fructose 2,6 bis phosphate
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14) Megnesium is needed for the activity of which enzymes ? a. Phosphatase b. Aldolase c. Dismutase d. ATPase
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15) When the prosthetic group of an enzyme is an inorganic ion, it is called a_____________? a. Cofactor b. Coenzyme c. Apoenzyme d. Holoenzyme
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16) Coenzyme, in an enzymatic reaction usually functions to_____________? a. Activate the substrate b. Increase the active sites of apoenzyme c. Enhance the specificity of apoenzyme d. Accept one of the cleavage products
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17) The most common enzyme deficiency in man is___________? a. Glucose 6 phosphate dehydrogenase b. Glucose 6 phosphatase c. Hexokinase d. Glucose 1,6 diphosphatase
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18) Enzymes concerned with the citric acid cycle are found in______________? a. Nucleus b. Mitochondria c. Ribosomes d. Non-particulate cytoplasm
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19) Serum alkaline phosphatase level increase in_______________? a. Hypothyroidism b. Carcinoma of prostate c. Hyperparathyroidism d. Myocardial infarction
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20) The enzyme that splits hydrogen peroxide into water and oxygen is_____________? a. Cytochromes b. Cytochrome P 450 c. Super oxide dismutase d. Catalase
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21) Enzyme that catalyses the transfer of a molecule group from one molecule to another is_____________? a. Oxidases b. Peptidases c. Transferases d. LIpases
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22) The activity of this plasma enzyme is responsible virtually for all plasma cholesterol esters in humans_______________? a. Lecithin cholesterol acyl transferase (LCAT) b. Pyrophospho mevalonate decarboxylase c. HMG CoA reductase d. Phospho mevalonate kinase
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23) Enzymes are classified according to_________________? a. Action on substrate b. Action of coenzymes c. Nature of the enzymes d. All of the above
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24) Fraction of CPK is an enzyme that is elevated in a myocardial infarct is____________________? a. MM fraction b. MB fraction c. BB fraction d. Both MM and BB fraction
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25) A material that speeds up a chemical reaction without chemically becoming involved is called_____________? a. A solvent b. A base c. A catalyst d. Thermoplastic
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26) Km of an enzyme is_____________? a. Dissociation constant b. The normal physiological substrate concentration c. Substrate concentration at half maximal velocity d. Numerically identical for all isozymes that catalyses a given reaction
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27) Acetyl Co-A acts as a substrate for all the enzymes except______________? a. HMG-Co A synthase b. Malic enzyme c. Malonyl CoA synthetase d. Fatty acid synthetase
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28) The enzyme that is specifically increased in obstructive jaundice is_____________? a. Glutamate oxaloacetate transaminase b. Glutamate pyruvate transaminase c. Alkaline phosphaase d. Acid phosphatase
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29) Elevated levels of serum glutamic oxaloacetic transaminase in indicative of______________? a. Deficiency of glutamic acid b. Deficiency of oxaloacetic acid c. Liver disease d. All of the above
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30) Muscle glycogen, which cannot contribute to blood glucose due to the absence of which enzymes ? a. Phosphoglutamase b. Branching enzyme c. Debranching enzyme d. Glucose-6-phosphotase
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